Improving Effect on Oral Conditions with Dentifrice Combined by Extracts of Dipotassium Glycyrrhizinate, Bamboo Salt and Quantitative Extracts of Centella Asiatica
박용덕, Nam Dong-Wang, 성정민, 황지민, 김지현, 이선경, Ahn Kwang-Sik, 유수민, 조자원, 문교태, 이설훈, 안재현,
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박용덕 ( Park Yong-Duk ) - Kyung Hee University School of Dentistry Department of Preventive and Social Dentistry & Institute of Oral Biology
( Nam Dong-Wang ) - Kyung Hee University School of Dentistry Department of Preventive and Social Dentistry & Institute of Oral Biology
성정민 ( Seong Jeong-Min ) - Kyung Hee University School of Dentistry Department of Preventive and Social Dentistry & Institute of Oral Biology
황지민 ( Hwang Ji-Min ) - Kyung Hee University School of Dentistry Department of Preventive and Social Dentistry & Institute of Oral Biology
김지현 ( Kim Ji-Hyun ) - Kyung Hee University School of Dentistry Department of Preventive and Social Dentistry & Institute of Oral Biology
이선경 ( Lee Sun-Kyoung ) - Kyung Hee University School of Dentistry Department of Preventive and Social Dentistry & Institute of Oral Biology
( Ahn Kwang-Sik ) - Kyung Hee University School of Dentistry Department of Preventive and Social Dentistry & Institute of Oral Biology
유수민 ( Yoo Su-Min ) - Dong-U College Department of Dental Hygiene
조자원 ( Cho Ja-Won ) - Dankook University School of Dentistry Department of Preventive Dentistry
문교태 ( Moon Kyo-Tae ) - LG Household & Health Care Research Park
이설훈 ( Lee Seol-Hoon ) - LG Household & Health Care Research Park
안재현 ( Ahn Jae-Hyun ) - LG Household & Health Care Research Park
KMID : 1157520100060020089
Abstract
Objective: This experiment was contrived to find out the changed in oral condition index when standardized and regular use of the dentifrice is done according to the usage of dosage of the dentifrice.
Methods: After inspecting the result of acceleration of collagen forming and suppressing effect of inflammatory reaction by using the titrated extracts of Centella asiatica and Dipotassium glycyrrhizinate with In-vitro experiment (done inside the lab), the remedying effect on oral cavity condition was to be obtained with dentifrice made with combined bamboo salt and those above through in-vivo experiment (clinical) worked with 90 healthy bodied examinees for over 6 months.
Results: With the result of the experiment done at the lab, when the changes of improved index of oral cavity condition, MMP-1 formative inhibition analysis, and collagen analysis were obtained during the experiment periods, the titrated extract of Centella asiatica suppresses the damage of the tissue due to inflammatory response at the gingiva cell and after the inflammatory response, accelerated regeneration of the gingiva were clearly shown. Also, as with the result in clinical experiment, the effect was acceptable in reducing effect of dental plaque index and gingivitis index with dentifrice that only contains the titrated extract of Centella asiatica and also showed outstanding result in antibacterial activity.
Conclusion: The most effective improvement especially shown on the oral conditions were dentifrice that contains Dipotassium glycyrrhizinate, bamboo salt and titrated extracts of Centella asiatica.
키워드
bamboo salt; centella asiatica; dipotassium glycyrrhizinate; toothpaste
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